The Brow Lab group photo

Welcome to the Brow lab! We are trying to understand how the chemical properties of RNA and protein have been exploited by evolution to enable complex biological processes, such as pre-mRNA splicing and transcription termination. We use the awesome power of brewer’s yeast genetics, genomics, and biochemistry to explore the workings of two biological nanomachines: the spliceosome and RNA polymerase. Check out our “Research” page for an overview of our studies, and the “Publications” page for our recent work. Also check out the “Lab Members” page to find out what our past members are up to now!

Click below to learn more about the latest news and publications out of the Brow Lab!

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Brow Lab News

Jan. 2024: Excited to host Josh Arribere for Genetics seminar!
Dec. 2023: Kylie competes in the ugly sweater contest.

July 2023: Send off for Justin to the NIH!
May 2023: Congratulations to Emma and Justin on their graduation!
Jan. 2023: Welcome to our new IPiB PhD student, Moyao Wang!
Oct. 2022: Dave & Emma attend the ASBMB transcription meeting at Snowbird.
August 2022: Congratulations to Erica on receiving her PhD!
June 2022: Congratulations to Justin on his poster award at RNA 2022!
June 2022: The Brow lab at the RNA Society meeting in Boulder, CO!

May 2022: Celebrating the 101st anniversary of our department at BMC101.

May 2022: Honored to host David Bentley for an RNA MaxiGroup talk!
May 2022: Undergrad Annika presents a poster on her project!

Jan. 2022: We are excited to welcome Kylie Zawisza to our lab for her PhD studies in the IPiB program!

Recent Publications

E.C. Goguen, D.A. Brow. (2023) Domains and residues of the Saccharomyces cerevisiae hnRNP protein Hrp1 important for transcriptional autoregulation and noncoding RNA termination.

K.A. Lipinski, J.Chi, X. Chen, A.A. Hoskins, and D.A. Brow. (2022) Yeast U6 snRNA made by RNA polymerase II is less stable but functional.

Mabin, J.W., P.W. Lewis, D.A. Brow, and H. Dvinge. (2021). Human spliceosomal snRNA sequence variants generate variant spliceosomes. RNA 27: 1186-1203

Montemayor EJ, Virta JM, Hayes SM, Nomura Y, Brow DA, Butcher SE. (2020). Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes. RNA 26:1400-1413. PMCID: PMC7491322

Brow DA. (2019) An allosteric network for spliceosome activation revealed by high-throughput suppressor analysis in Saccharomyces cerevisiae. Genetics 212:111-124. PMCID: PMC6499515 (Highlighted article)

Didychuk AL, Butcher SE, Brow DA. (2018) The life of U6 small nuclear RNA, from cradle to grave. RNA 24:437-460. (Review) corresponding author

Montemayor EJ, Didychuk AL, Yake AD, Sidhu GK, Brow DA, Butcher SE. (2018) Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA. Nature Communications 9:1749. corresponding authors