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Welcome to the Brow lab! We are trying to understand how the chemical properties of RNA and protein have been exploited by evolution to enable complex biological processes, such as pre-mRNA splicing and transcription termination. We use the awesome power of brewer’s yeast genetics, genomics, and biochemistry to explore the workings of two biological nanomachines: the spliceosome and RNA polymerase. (Some of us also use brewer’s yeast to brew beer!) Check out our “Research” page for an overview of our studies, and the “Publications” page for our recent work. Also check out the “Lab Members” page to find out what our past members are up to now!

Click on the tabs below to learn the latest News and Publications of the Brow Lab!

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Brow Lab News

Congratulations to Allyson Yake, who was awarded a Ruth L. Kirschstein NRSA predoctoral fellowship from NIGMS to support her thesis studies on the mechanism of pre-mRNA splicing! (July 2018)

Welcome to undergraduate Audun Saterbak, who is establishing CRISPR genome editing technology in our lab. (August 2017)

Congratulations to past graduate student Xin Chen, whose second first-author paper from his thesis studies was recently published in PLOS Genetics! (August 2017)

Welcome to Emma Goguen, a first-year IPiB student who has joined the Brow lab for her thesis research! Emma was an undergraduate at UC Davis, where she majored in Biochemistry and Molecular Biology and conducted research with Prof. Stacey Harmer. (February 2017)

Congratulations to Dr. Eric Montemayor for his promotion to Associate Scientist in the Brow and Butcher labs! (August 2016)

Recent Publications

Didychuk AL, Butcher SE, Brow DA. (2018) The life of U6 small nuclear RNA, from cradle to grave. RNA 24:437-460. (Review) corresponding author

Montemayor EJ, Didychuk AL, Yake AD, Sidhu GK, Brow DA, Butcher SE. (2018) Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA. Nature Communications 9:1749. corresponding authors

Chen X, Poorey K, Wells, MN, Müller U, Bekiranov S, Auble, DT, Brow, DA (2017) Transcriptomes of six mutants in the Sen1 pathway reveal combinatorial control of transcription termination across the Saccharomyces cerevisiae genome. PLOS Genetics, 13:e1006863.

Montemayor EJ, Didychuk AL, Liao H, Hu P, Brow DA, Butcher SE (2017) Structure and conformational plasticity of the U6 small nuclear ribonucleoprotein core. Acta Cryst. D Struct. Biol., 73, 1-8.

Rodgers ML, Didychuk AL, Butcher SE, Brow DA, Hoskins AA (2016) A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex. Nucl. Acids Res., 44, 10912-10928.