Welcome to the Brow lab! We are trying to understand how the chemical properties of RNA and protein have been exploited by evolution to enable complex biological processes, such as pre-mRNA splicing and transcription termination. We use the awesome power of brewer’s yeast genetics, genomics, and biochemistry to explore the workings of two biological nanomachines: the spliceosome and RNA polymerase. Check out our “Research” page for an overview of our studies, and the “Publications” page for our recent work. Also check out the “Lab Members” page to find out what our past members are up to now!
Click below to learn more about the latest news and publications out of the Brow Lab!
Oct. 2026: Our RNA manuscript (Zawisza et al.) is accepted!
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June 2026: Dave gives a talk at the Yeast Genetics Meeting in Asilomar, CA
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April 2026: Excited to host Nicholas Ingolia for Biochemistry Colloquium!
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March 2026: Our RNA manuscript (Goguen et al.) is accepted!
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Nov. 2025: Excited to host Jeremy Wilusz for a RNA MaxiGroup talk!
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Oct. 2025: Our Genetics manuscript (Moyao Wang et al.) is accepted!
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Sept. 2025: Ben Gardner, son of past Brow lab undergrad Jeremy Gardner, starts an independent study project.
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June 2025: Emma, Kylie, and Moyao attend RNA 2025 in San Diego, CA. Emma gave a talk and Kylie and Moyao presented posters.
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Sept. 2024: Excited to host Rachel Niederer for Biochemistry Colloquium!
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May 2024: Emma, Kylie, and Dave attend the RNA Society Annual Meeting in Edinburgh and had a wonderful dinner out with past grad Jason Kuehner.
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May 2024: Dave serves as “opponent” for Antto Norppa’s thesis defense in Helsinki. (He passed with honors!)
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May 2024: Mirra Blehert (daughter of past grad Regina Vidaver) starts a summer project in the Brow lab.
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April 2024: Congratulations to Moyao on passing his prelim exam!
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Jan. 2024: Excited to host Josh Arribere for Genetics seminar!
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Dec. 2023: Kylie competes in the ugly sweater contest.
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July 2023: Send off for Justin to Bobby Hogg’s lab at NIH!
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May 2023: Congratulations to Emma and Justin on their graduation!
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April 2023: Congratulations to Kylie on passing her prelim exam!
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Jan. 2023: Welcome to our new IPiB PhD student, Moyao Wang!
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April 2023: Congratulations to Kylie on passing her prelim exam!
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Oct. 2022: Dave & Emma attend the ASBMB transcription meeting at Snowbird.
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August 2022: Congratulations to Erica on receiving her PhD!
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June 2022: Congratulations to Justin on his poster award at RNA 2022!
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June 2022: The Brow lab at the RNA Society meeting in Boulder, CO.
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May 2022: Celebrating the 101st anniversary of our department at BMC101!
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May 2022: Honored to host David Bentley for an RNA MaxiGroup talk!
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May 2022: Undergrad Annika presents a poster on her project.
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Jan. 2022: We are excited to welcome Kylie Zawisza to our lab for her PhD studies in the IPiB program!
Zawisza KA, Goguen EC, Brow DA. (2026). Substitutions in the yeast Nrd1 RNA-binding domain have distinct effects on NNS terminator recognition. RNA doi: 10.1261/rna.081283.126.
Brow DA. (2026). Past studies suggest potential therapies for newly discovered retinitis pigmentosa mutations in U6 and U4 snRNAs. RNA 32:1195-1198.
Goguen EC, Zawisza KA, Brow DA. (2026). Direct RNA-seq provides evidence for an antiterminator function of the yeast Hrp1 protein on RNA polymerase II transcripts. RNA 32:1115-1128.
Wang M, Arora P, Kaplan CD, Brow DA. (2026). Substitutions in RNA-binding protein Hrp1 map a potential interaction surface with the yeast RNA polymerase II elongation complex. Genetics 232:iyaf225.
Shand EL, Sweeney K, Sundling KE, McClean MN, Brow DA. (2024). Live-cell analysis of IMPDH protein levels during yeast colony growth provides insights into the regulation of GTP synthesis. mBio 15:e0102124.
Goguen EC, Brow DA. (2023). Domains and residues of the Saccharomyces cerevisiae hnRNP protein Hrp1 important for transcriptional autoregulation and noncoding RNA termination. Genetics 225:iyad134.
Lipinski KA, Chi J, Chen X, Hoskins AA, and Brow DA. (2022). Yeast U6 snRNA made by RNA polymerase II is less stable but functional. RNA 28:1606-1620.
Mabin JW, Lewis PW, Brow DA, and Dvinge H. (2021). Human spliceosomal snRNA sequence variants generate variant spliceosomes. RNA 27:1186-1203.