Publications

Some recent publications

Perform a customized PubMed literature search for Dr. Brow.

• Zawisza KA, Goguen EC, Brow DA. (2026) Substitutions in the yeast Nrd1 RNA-binding domain have distinct effects on NNS terminator recognition.
• Brow DA. (2026) Past studies suggest potential therapies for newly discovered retinitis pigmentosa mutations in U6 and U4 snRNAs.
• Goguen EC, Zawisza KA, Brow DA. (2026) Direct RNA-seq provides evidence for an antiterminator function of the yeast Hrp1 protein on RNA polymerase II transcripts.
• Wang M, Arora P, Kaplan CD, Brow DA. (2026) Substitutions in RNA-binding protein Hrp1 map a potential interaction surface with the yeast RNA polymerase II elongation complex.
• Shand EL, Sweeney K, Sundling KE, McClean MN, Brow DA. (2024) Live-cell analysis of IMPDH protein levels during yeast colony growth provides insights into the regulation of GTP synthesis.
• Goguen EC, Brow DA. (2023) Domains and residues of the Saccharomyces cerevisiae hnRNP protein Hrp1 important for transcriptional autoregulation and noncoding RNA termination.
• Lipinski KA, Chi J, Chen X, Hoskins AA, Brow DA. (2022) Yeast U6 snRNA made by RNA polymerase II is less stable but functional.
• Mabin JW, Lewis PW, Brow, DA and Dvinge H. (2021) Human spliceosomal snRNA sequence variants generate variant spliceosomes.
• Brow DA. (2019) An allosteric network for spliceosome activation revealed by high-throughput suppressor analysis in Saccharomyces cerevisiae.
• Didychuk AL, Butcher SE, Brow DA. (2018) The life of U6 small nuclear RNA, from cradle to grave.
• Montemayor EJ, Didychuk AL, Yake AD, Sidhu GK, Brow DA, Butcher SE. (2018) Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA.
• Chen X, Poorey K, Wells MN, Müller U, Bekiranov S, Auble DT, Brow DA. (2017) Transcriptomes of six mutants in the Sen1 pathway reveal combinatorial control of transcription termination across the Saccharomyces cerevisiae genome.
• Rodgers ML, Didychuk AL, Butcher, SE, Brow DA, and Hoskins AA. (2016) A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex.
• Didychuk AL, Montemayor EJ, Brow DA, Butcher SE. (2016) Structural requirements for protein-catalyzed annealing of U4 and U6 RNAs during di-snRNP assembly.
• Martin-Tumasz S, Brow DA. (2015). Saccharomyces cerevisiae Sen1 helicase domain exhibits 5’ to 3’ helicase activity with a preference for translocation on DNA rather than RNA.
• Brow, DA. (2015) An RNA mystery and its denouement.
• Burke, JE, Butcher SE, and Brow DA. (2015) Spliceosome assembly in the absence of stable U4/U6 RNA pairing.
• Chen X, Müller U, Sundling KE, Brow DA (2014) Saccharomyces cerevisiae Sen1 as a model for the study of mutations in human Senataxin that elicit cerebellar ataxia.
• Montemayor EJ, Curran EC, Liao HH, Andrews KL, Treba CN, Butcher SE, Brow DA. (2014). Core structure of the U6 snRNP at 1.7 Å resolution.
• Price AM, Görnemann J, Guthrie C, and Brow DA (2014). An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8.
• Brow DA (2011). Sen-sing RNA terminators.
• Brow DA. (2009). Eye on RNA unwinding.
• Kuehner JN, Brow DA. (2008). Regulation of a eukaryotic gene by GTP-dependent start site selection and transcription attenuation.
• McManus CJ, Schwartz ML, Butcher SE, Brow DA. (2007). A dynamic bulge in the U6 RNA internal stem-loop functions in spliceosome assembly and activation.
• Bae E, Reiter NJ, Bingman CA, Kwan SS, Lee D, Phillips GN, Butcher SE, and Brow DA. (2007). Structure and interactions of the first three RNA recognition motifs of splicing factor Prp24.
• Steinmetz EJ, Warren CL, Kuehner JN, Panbehi B, Ansari AZ, Brow DA. (2006). Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase.